Valproate pivoxil

Valproate pivoxil is a prodrug of valproic acid, a medication primarily used to treat epilepsy and bipolar disorder and to prevent migraine headaches. It is also used to treat schizophrenia along with other medications and as a second line option in major depressive disorder. It is taken by mouth.

Mechanism of Action

Valproate pivoxil is converted to valproic acid in the stomach. The exact mechanism of action of valproate is not fully understood. However, it is believed to affect the function of the neurotransmitter GABA (as a GABA transaminase inhibitor) in the human brain, making it an alternative choice for patients who are unable to tolerate the side effects of other treatments.

Side Effects

Common side effects of valproate pivoxil include nausea, vomiting, dizziness, and tremor. Serious side effects can include liver problems, pancreatitis, suicidal thoughts, low blood platelets, and encephalopathy. It is known to cause serious abnormalities in babies if taken during pregnancy, so it is not recommended for pregnant women or women who may become pregnant.

Interactions

Valproate pivoxil can interact with a number of other medications, including other antiepileptic drugs, certain antidepressants, and certain antibiotics. It is important to inform your healthcare provider of all medications you are currently taking to avoid potential interactions.

Dosage

The dosage of valproate pivoxil varies depending on the condition being treated. It is typically started at a low dose, which is then gradually increased until the desired effect is achieved.

See Also

• Valproic acid
• Prodrug
• Epilepsy
• Bipolar disorder
• Migraine

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