Xanthogranulomatous inflammation

Xanthogranulomatous inflammation is a rare form of chronic inflammation characterized by the presence of large numbers of foam cells, or lipid-laden macrophages, in a granulomatous setting. This type of inflammation is most commonly associated with kidney disease, but can occur in other organs as well.

Etiology

The exact cause of xanthogranulomatous inflammation is not well understood. It is thought to be a response to chronic infection or long-standing inflammation, particularly in the presence of obstructive uropathy. The inflammation may also be associated with certain types of bacteria, such as Escherichia coli and Proteus mirabilis, which can cause urinary tract infections.

Pathology

In xanthogranulomatous inflammation, the affected tissue is replaced by a mixture of lipid-laden macrophages, lymphocytes, plasma cells, and multinucleated giant cells. The macrophages, which are a type of white blood cell, contain large amounts of lipids, giving them a foamy appearance. This is a distinctive feature of xanthogranulomatous inflammation.

Clinical Features

Patients with xanthogranulomatous inflammation may present with a variety of symptoms, depending on the organ involved. In cases of xanthogranulomatous pyelonephritis, a form of kidney inflammation, symptoms may include flank pain, weight loss, and recurrent urinary tract infections. In cases involving the gallbladder, symptoms may include abdominal pain and jaundice.

Diagnosis

Diagnosis of xanthogranulomatous inflammation is typically made through histopathological examination of tissue samples obtained through biopsy or surgical resection. Imaging studies, such as computed tomography (CT) scans or magnetic resonance imaging (MRI), may also be used to identify the extent of the inflammation and any associated complications.

Treatment

Treatment of xanthogranulomatous inflammation typically involves addressing the underlying cause of the inflammation, such as treating any associated infections or relieving any obstructions. In severe cases, surgical removal of the affected organ may be necessary.

See Also

• Chronic inflammation
• Macrophage
• Pyelonephritis