Ymer
YES1
YES1 is a proto-oncogene that encodes a member of the Src family of tyrosine kinases, which are involved in the regulation of various cellular processes, including growth, differentiation, and survival. YES1 is located on chromosome 18 in humans and is expressed in a variety of tissues.
Structure[edit | edit source]
YES1 is a non-receptor tyrosine kinase that shares a common structure with other Src family kinases. It consists of several domains:
- SH3 domain: This domain is involved in protein-protein interactions and binds to proline-rich sequences in other proteins.
- SH2 domain: This domain binds to phosphorylated tyrosine residues, allowing YES1 to interact with other phosphorylated proteins.
- Kinase domain: This is the catalytic domain responsible for the transfer of a phosphate group from ATP to tyrosine residues on substrate proteins.
- Regulatory domain: This domain contains sites for phosphorylation that regulate the activity of the kinase.
Function[edit | edit source]
YES1 plays a critical role in several cellular processes:
- Cell growth and proliferation: YES1 is involved in signaling pathways that promote cell division and growth.
- Cell adhesion and migration: It regulates the dynamics of the cytoskeleton, affecting how cells adhere to each other and move.
- Survival signaling: YES1 can activate pathways that prevent apoptosis, thereby promoting cell survival.
Clinical Significance[edit | edit source]
YES1 has been implicated in various cancers due to its role in cell proliferation and survival. Overexpression or hyperactivation of YES1 can lead to uncontrolled cell growth, a hallmark of cancer. It is considered a potential target for cancer therapy, and inhibitors of YES1 are being investigated for their therapeutic potential.
Research and Therapeutic Targeting[edit | edit source]
Research into YES1 focuses on understanding its role in cancer and developing inhibitors that can selectively target its kinase activity. Several small molecule inhibitors are in development, aiming to block the aberrant signaling pathways driven by YES1 in cancer cells.
Also see[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
