ZAP-70 deficiency

From WikiMD's Wellnesspedia

(Redirected from ZAP70 deficiency)

Other Names[edit | edit source]

Zeta-associated-protein 70 deficiency; Severe combined immunodeficiency due to ZAP70 deficiency

Definition[edit | edit source]

A very rare, severe, genetic, combined immunodeficiency  disorder characterized by lymphocytosis, decreased peripheral CD8+ T-, and presence of normal circulating CD4+ T-cells, leading to immune dysfunction.

Pathophysiology[edit | edit source]

ZAP-70 deficiency is a very rare, genetic, combined immunodeficiency disorder characterized by the following:

Symptoms[edit | edit source]

80%-99% of people have these symptoms

  • Decreased lymphocyte proliferation in response to mitogen
  • Recurrent opportunistic infections
  • Recurrent viral infections

30%-79% of people have these symptoms

ZAP-70 deficiency Resources

Find a healthcare provider anywhere in the world quickly and easily!

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski

WikiMD.png


WikiMD is the world's largest, free medical and wellness encyclopedia edited only by professionals. Advertise!



NIH genetic and rare disease info[edit source]

ZAP-70 deficiency is a rare disease.


Wiki.png

Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD


Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD

WikiMD is not a substitute for professional medical advice. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.