Zinc finger protein 197

Zinc finger protein 197 (ZNF197) is a protein that in humans is encoded by the ZNF197 gene. This protein is a member of the zinc finger family of proteins, which are characterized by the presence of zinc finger domains. These domains are known to play a crucial role in DNA binding and protein-protein interactions.

Structure

ZNF197 is a large protein, consisting of 1,053 amino acids. It contains 14 C2H2-type zinc finger domains, which are the most common type of zinc finger domain. These domains are characterized by two cysteine residues and two histidine residues that coordinate a zinc ion, forming a stable structure that can interact with DNA, RNA, or other proteins.

Function

The exact function of ZNF197 is not fully understood. However, like other zinc finger proteins, it is believed to be involved in gene regulation. Zinc finger proteins typically act as transcription factors, binding to specific sequences of DNA and influencing the activity of other genes. This can affect a wide range of biological processes, from cell growth and differentiation to apoptosis.

Clinical significance

Mutations in the ZNF197 gene have been associated with a number of health conditions. For example, a study published in the journal Nature Genetics found a link between variations in the ZNF197 gene and an increased risk of schizophrenia. Further research is needed to fully understand the role of ZNF197 in disease.

See also

• Zinc finger
• Transcription factor
• Gene regulation