2,5-Dimethoxy-4-amylamphetamine

2,5-Dimethoxy-4-amylamphetamine (DOAM) is a psychedelic drug and a member of the DOx family of compounds which are known for their high potency, long duration, and mixture of psychedelic and stimulant effects.

Chemistry

2,5-Dimethoxy-4-amylamphetamine is a substituted amphetamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. DOAM contains two methoxy functional groups CH3O- which are attached to carbons R2 and R5 as well as an amyl chain bound to carbon R4 of the phenyl ring.

Pharmacology

The mechanism that produces the hallucinogenic and entheogenic effects of DOAM is most likely to result from action as a 5-HT2A receptor agonist in the brain, a mechanism of action shared by various hallucinogenic drugs such as LSD and psilocin.

Effects

The effects of DOAM are reported to be extremely strong and long-lasting. Users report intense visuals, increased energy, and altered thought processes. The effects can last up to 24 hours, with the peak usually occurring in the first few hours.

Risks

As with all psychedelic substances, the use of DOAM carries the risk of triggering a psychotic or manic episode in susceptible individuals. It is also possible to experience a bad trip, which can be extremely distressing and psychologically damaging.

Legal Status

The legal status of DOAM varies by country, but it is generally considered a controlled substance under the United Nations Convention on Psychotropic Substances.

See Also

• DOx
• Psychedelic drug
• Substituted amphetamine