3,4-Methylenedioxyphenethylamine
3,4-Methylenedioxyphenethylamine (MDPEA), also known as homopiperonylamine, is a substituted phenethylamine and a ring-substituted amphetamine derivative. It is a close structural analogue of 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA), better known as "ecstasy".
Chemistry[edit | edit source]
MDPEA is a phenethylamine derivative, with the phenethylamine core structure consisting of a phenyl ring bound to an amino (NH2) group through an ethyl chain. MDPEA has substitutions at R3 and R4 of the phenyl ring with methylenedioxy functional groups (O-CH2-O).
Pharmacology[edit | edit source]
The pharmacological properties of MDPEA are not well-studied. However, it is known that it does not produce the stimulant or entactogen effects of its analogues MDA and MDMA, as it lacks their methamphetamine backbone. It is believed to act as a monoamine oxidase inhibitor (MAOI), and may increase the levels of serotonin, dopamine, and norepinephrine in the brain.
Toxicity[edit | edit source]
The toxicity of MDPEA is not well-studied. However, due to its structural similarity to other amphetamines, it may potentially have similar side effects, including hypertension, hyperthermia, and serotonin syndrome when combined with other serotonergic drugs.
Legal Status[edit | edit source]
In the United States, MDPEA is not a controlled substance, although it could potentially be considered an analogue of MDA or MDMA under the Federal Analogue Act.
See Also[edit | edit source]
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