3-hydroxyphencyclidine
3-Hydroxyphencyclidine (3-HO-PCP) is a dissociative hallucinogen that is related to phencyclidine (PCP). It is a potent NMDA receptor antagonist with a distinctive set of effects that set it apart from other dissociatives.
Chemistry[edit | edit source]
3-Hydroxyphencyclidine is a member of the aryl cyclohexylamine class. It is structurally related to phencyclidine (PCP) and more specifically, is a single hydroxy group derivative of PCP. The name 3-Hydroxyphencyclidine refers to the position of the hydroxy group on the phenyl ring.
Pharmacology[edit | edit source]
As an NMDA receptor antagonist, 3-HO-PCP inhibits the action of the NMDA receptor, a specific subtype of the glutamate receptor. This results in a decrease in the overall level of neuronal excitability, leading to the drug's dissociative effects.
Effects[edit | edit source]
The effects of 3-HO-PCP can vary greatly depending on the dose and individual's physiology. Common effects include dissociation, hallucination, and euphoria. At higher doses, it can cause delirium, amnesia, and psychosis.
Risks[edit | edit source]
Like other NMDA receptor antagonists, 3-HO-PCP has the potential for serious side effects. These can include psychosis, neurotoxicity, and addiction. It is also possible to experience a bad trip or overdose on 3-HO-PCP.
Legal Status[edit | edit source]
The legal status of 3-HO-PCP varies by country. In some countries, it is a controlled substance, while in others it is legal to possess for personal use.
See Also[edit | edit source]
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