5-HT1

5-HT1 receptor is a subtype of 5-HT receptor that binds to the neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and is known to inhibit the release of neurotransmitter and neural activity. The 5-HT1 receptors are widespread in the central nervous system and can be divided into 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F, each with a distinct pharmacological profile and distribution within the brain.

Function[edit | edit source]

The 5-HT1 receptors play a role in various processes such as anxiety, depression, emesis, pain, and appetite. They are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, and anxiolytics.

Subtypes[edit | edit source]

The 5-HT1 receptor subtypes are all inhibitory, except for the 5-HT1C receptor, which is excitatory. The different subtypes have different physiological and pharmacological characteristics.

5-HT1A[edit | edit source]

The 5-HT1A receptor is located in the raphe nucleus, hippocampus, cerebral cortex, and spinal cord. It is thought to play a key role in the pathophysiology of depression.

5-HT1B[edit | edit source]

The 5-HT1B receptor is located in the basal ganglia, striatum, and frontal cortex. It is thought to be involved in the regulation of mood and the action of antidepressant drugs.

5-HT1D[edit | edit source]

The 5-HT1D receptor is located in the trigeminal ganglion, hypothalamus, and substantia nigra. It is thought to be involved in the regulation of migraine.

5-HT1E[edit | edit source]

The 5-HT1E receptor is located in the cerebral cortex and hippocampus. Its function is not well understood.

5-HT1F[edit | edit source]

The 5-HT1F receptor is located in the cerebral cortex, cerebellum, and thalamus. It is thought to be involved in the regulation of migraine.

See also[edit | edit source]

5-HT1 Resources
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