5-HT1D
5-HT1D is a subtype of the 5-HT receptor that binds to the neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and inhibits the release of neurotransmitters. The 5-HT1D receptor is found in the central nervous system (CNS), particularly in the basal ganglia and the frontal cortex.
Function[edit | edit source]
The 5-HT1D receptor is involved in a variety of functions in the body. It plays a role in the regulation of serotonin release, which can affect mood and behavior. It is also involved in the regulation of blood pressure and heart rate, and can influence the release of other neurotransmitters such as dopamine and norepinephrine.
Clinical significance[edit | edit source]
The 5-HT1D receptor is a target for the treatment of migraines. Drugs that activate this receptor, such as triptans, can help to relieve the symptoms of migraines. In addition, the 5-HT1D receptor is also a potential target for the treatment of depression and anxiety disorders.
See also[edit | edit source]
References[edit | edit source]
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