5-HT2

5-HT2 receptors are a subfamily of 5-HT receptors that bind the endogenous neurotransmitter serotonin, also known as 5-hydroxytryptamine (5-HT). They are located on the smooth muscle cells in the walls of blood vessels and the gastrointestinal tract, as well as in the central nervous system.

Structure and function

The 5-HT2 receptor family consists of three subtypes: 5-HT2A, 5-HT2B, and 5-HT2C. These receptors are G protein-coupled receptors (GPCRs), meaning they activate an intracellular second messenger cascade to produce their effects.

Clinical significance

5-HT2 receptors have been implicated in various psychiatric disorders, including depression, anxiety, and schizophrenia. They are also involved in the regulation of mood, appetite, and sleep. Drugs that act on these receptors can have therapeutic effects in these conditions.

Pharmacology

Many drugs act on 5-HT2 receptors, either as agonists (activating the receptor) or antagonists (blocking the receptor). These include certain antidepressants, antipsychotics, and hallucinogens.

See also

• 5-HT receptor
• Serotonin
• G protein-coupled receptor

References

5-HT2 Resources
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