Drotaverine
(Redirected from Abdrot)
Drotaverine is a phosphodiesterase 4 inhibitor, a type of drug that is primarily used as an antispasmodic. It is manufactured and marketed under several trade names worldwide.
Etymology[edit | edit source]
The term "Drotaverine" is derived from the chemical name of the drug, which is 1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline.
Pharmacology[edit | edit source]
Drotaverine is a phosphodiesterase 4 inhibitor, which means it works by inhibiting the enzyme phosphodiesterase 4 (PDE4). This inhibition leads to an increase in cyclic AMP, which in turn relaxes smooth muscle, thus reducing muscle spasms and pain.
Medical uses[edit | edit source]
Drotaverine is used to treat a variety of conditions that involve spasms of smooth muscle. These include gastrointestinal spasm, biliary colic, renal colic, and cervical spasm during labor. It is also used in the treatment of dysmenorrhea (painful periods).
Side effects[edit | edit source]
Like all drugs, Drotaverine can cause side effects, although not everyone experiences them. Common side effects include nausea, vomiting, dry mouth, and vertigo. Less common side effects include palpitations, headache, and constipation.
Contraindications[edit | edit source]
Drotaverine should not be used in people with severe heart disease, liver disease, or kidney disease. It is also contraindicated in people with a known hypersensitivity to the drug.
Interactions[edit | edit source]
Drotaverine can interact with other drugs, including levodopa, which is used to treat Parkinson's disease. This interaction can lead to a decrease in the effectiveness of levodopa.
See also[edit | edit source]
- Phosphodiesterase 4 inhibitor
- Antispasmodic
- Gastrointestinal spasm
- Biliary colic
- Renal colic
- Cervical spasm
- Dysmenorrhea
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Contributors: Prab R. Tumpati, MD