Adenosine Reuptake Inhibitor

Adenosine Reuptake Inhibitor

An adenosine reuptake inhibitor (ARI) is a type of drug that inhibits the reuptake of adenosine by cells. This action increases the concentration of adenosine in the extracellular space, leading to increased adenosine signaling. ARIs are used in the treatment of various medical conditions, including cardiovascular disease, neurological disorders, and cancer.

Mechanism of Action[edit | edit source]

ARIs work by blocking the transporter proteins that normally remove adenosine from the extracellular space. These proteins, known as equilibrative nucleoside transporters (ENTs), are found in the cell membrane and facilitate the movement of adenosine into and out of cells. By inhibiting ENTs, ARIs prevent the reuptake of adenosine, thereby increasing its extracellular concentration.

Therapeutic Uses[edit | edit source]

ARIs have a wide range of therapeutic uses. In the field of cardiology, they are used to treat conditions such as angina pectoris and supraventricular tachycardia. In neurology, they are used to manage seizures and neuropathic pain. Some ARIs also have antineoplastic properties and are used in the treatment of certain types of cancer.

Side Effects[edit | edit source]

Like all drugs, ARIs can cause side effects. These may include nausea, headache, dizziness, and fatigue. In rare cases, they may cause serious side effects such as bradycardia, hypotension, and dyspnea.