Axiron

Axiron is a topical solution used for testosterone replacement therapy (TRT) in males with conditions associated with a deficiency or absence of endogenous testosterone. It is applied to the underarm area using an applicator.

Medical Uses

Axiron is prescribed for the treatment of adult males with hypogonadism, a condition where the body does not produce enough testosterone. This can be due to primary hypogonadism (congenital or acquired) or secondary hypogonadism (due to pituitary or hypothalamic injury).

Administration

Axiron is administered topically to the skin of the underarm. The recommended starting dose is 60 mg of testosterone (1 pump actuation of 30 mg per underarm) applied once daily at the same time each morning. The dose may be adjusted based on serum testosterone levels.

Mechanism of Action

Testosterone is the primary male sex hormone and an anabolic steroid. Axiron works by delivering testosterone through the skin, which is then absorbed into the bloodstream. This helps to restore normal testosterone levels in men who have low testosterone due to certain medical conditions.

Side Effects

Common side effects of Axiron include:

• Skin irritation at the application site
• Increased red blood cell count
• Headache
• Diarrhea
• Increased blood pressure

Serious side effects may include:

• Cardiovascular events such as heart attack or stroke
• Prostate cancer
• Liver toxicity
• Polycythemia

Precautions

Patients using Axiron should avoid swimming or washing the application site for at least 2 hours after application to ensure proper absorption. It is also important to avoid skin-to-skin contact with others, especially women and children, to prevent secondary exposure to testosterone.

Related Pages

• Testosterone
• Hypogonadism
• Anabolic steroid
• Hormone replacement therapy
• Topical medication