BLZF1

BLZF1 is a gene that encodes a protein in humans. This protein is also known as Basic Leucine Zipper Nuclear Factor 1 or JEM-1 (Juxtaposed with another zinc finger protein 1). The BLZF1 gene is located on chromosome 1q24.2 and spans approximately 20 kilobases.

Function

The BLZF1 protein is a transcriptional repressor that plays a role in the regulation of cell growth. It is involved in the control of cellular proliferation and differentiation, and it may also play a role in the development of certain types of cancer. The protein contains a basic leucine zipper (bZIP) domain, which is a common feature of transcription factors. This domain allows the protein to bind to specific DNA sequences and regulate the expression of other genes.

Clinical Significance

Alterations in the BLZF1 gene have been associated with various types of cancer, including leukemia and lymphoma. In particular, overexpression of the BLZF1 protein has been observed in acute myeloid leukemia (AML) and may contribute to the development of this disease. Further research is needed to fully understand the role of BLZF1 in cancer and other diseases.

Research

Research on the BLZF1 gene and its protein product is ongoing, with studies focusing on its role in cell growth and differentiation, its potential involvement in cancer, and its possible use as a therapeutic target.

See Also

• Gene
• Protein
• Transcription factor
• Leukemia
• Lymphoma

References

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