Blue Fugates

  [[File:|frameless|alt=]]

Parent family
Country
Current region	Kentucky, United States
Earlier spellings
Etymology
Place of origin	Martin Fugate
Founded	1820s
Founder	Martin Fugate
Current head
Final ruler

The Blue Fugates were a family from the hills of Kentucky, notable for their blue-tinged skin. This unusual characteristic was due to a rare genetic condition known as methemoglobinemia, which results in an abnormal amount of methemoglobin, a form of hemoglobin, in the blood.

History

The Fugate family traces its origins to Martin Fugate, a French orphan who settled in the area around Hazard, Kentucky in the early 19th century. Martin married Elizabeth Smith, a local woman, and they had several children. Due to the isolated nature of the region, the family intermarried with other local families, including the Smiths, Combs, and Ritchies, which led to a high degree of genetic homogeneity.

Genetic Basis

The blue skin of the Fugates was caused by a condition called methemoglobinemia, which is inherited in an autosomal recessive pattern. This means that both parents must carry the gene for the condition to manifest in their offspring. The condition results in elevated levels of methemoglobin, which is less effective at carrying oxygen, leading to the blue appearance of the skin.

Medical Investigation

In the 1960s, Dr. Madison Cawein, a hematologist from the University of Kentucky, investigated the Fugate family. He discovered that the condition could be treated with methylene blue, a dye that acts as a reducing agent to convert methemoglobin back to normal hemoglobin, thus alleviating the symptoms.

Cultural Impact

The story of the Blue Fugates has captured the public's imagination and has been featured in various media, including books and documentaries. It serves as a fascinating example of how genetic conditions can manifest in isolated populations.

Also see

• Methemoglobinemia
• Genetic disorders
• Inbreeding
• Appalachian culture