Bone morphogenetic protein 4
| Bone Morphogenetic Protein 4 | |||||||
|---|---|---|---|---|---|---|---|
| 200px Structure of BMP4 | |||||||
| Identifiers | |||||||
| Symbol | ? | ||||||
| NCBI gene | 652 | ||||||
| HGNC | 1072 | ||||||
| OMIM | 112262 | ||||||
| RefSeq | NM_001202 | ||||||
| UniProt | P12644 | ||||||
| |||||||
Bone Morphogenetic Protein 4 (BMP4) is a protein that in humans is encoded by the BMP4 gene. It is a member of the transforming growth factor beta (TGF-β) superfamily, which is involved in the regulation of cellular growth, differentiation, and development in both embryonic and adult tissues.
Function[edit | edit source]
BMP4 plays a crucial role in the development of bone and cartilage. It is involved in the formation of the skeletal system, the nervous system, and the kidney. BMP4 is also important in the development of the heart, lung, and eye. It functions by binding to specific receptors on the surface of cells, initiating a signaling cascade that leads to changes in gene expression.
Mechanism of Action[edit | edit source]
BMP4 exerts its effects by binding to BMP receptors, which are serine/threonine kinase receptors. Upon ligand binding, these receptors phosphorylate SMAD proteins, which then translocate to the nucleus to regulate the transcription of target genes. This signaling pathway is critical for the regulation of cell fate decisions during embryonic development.
Clinical Significance[edit | edit source]
Mutations in the BMP4 gene have been associated with various developmental disorders. For example, alterations in BMP4 signaling can lead to craniofacial abnormalities, limb malformations, and congenital heart defects. BMP4 is also being studied for its potential role in cancer, as it can influence cell proliferation and differentiation.
Research and Applications[edit | edit source]
BMP4 is used in tissue engineering and regenerative medicine due to its ability to induce bone and cartilage formation. It is also a focus of research in stem cell biology, where it is used to direct the differentiation of pluripotent stem cells into specific cell types.
Also see[edit | edit source]
- Bone morphogenetic protein
- Transforming growth factor beta
- SMAD proteins
- Embryonic development
- Tissue engineering
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
