Cadralazine

Cadralazine

Cadralazine is a vasodilator that is used in the treatment of hypertension. It is a member of the hydrazinophthalazine class of drugs, which also includes dihydralazine and hydralazine. Cadralazine works by relaxing the smooth muscle in the walls of arteries and veins, which reduces the resistance to blood flow and lowers blood pressure.

Mechanism of Action

Cadralazine's mechanism of action is not fully understood, but it is believed to work by inhibiting the release of calcium ions in the smooth muscle cells of the blood vessels. This causes the muscle cells to relax, which dilates the blood vessels and reduces blood pressure. Cadralazine may also have a direct effect on the endothelium, the layer of cells that lines the inside of blood vessels, which can further enhance its vasodilatory effects.

Pharmacokinetics

After oral administration, cadralazine is rapidly absorbed from the gastrointestinal tract. It is metabolized in the liver and excreted in the urine. The half-life of cadralazine is approximately 2 to 4 hours, which allows for once or twice daily dosing.

Side Effects

Like all medications, cadralazine can cause side effects. The most common side effects are headache, dizziness, and tachycardia. Less common side effects include nausea, vomiting, and diarrhea. Rare but serious side effects include hypotension, angina pectoris, and myocardial infarction.

Contraindications

Cadralazine is contraindicated in patients with known hypersensitivity to hydrazinophthalazine derivatives. It should also be used with caution in patients with renal impairment or hepatic impairment, as these conditions can affect the metabolism and excretion of the drug.

Interactions

Cadralazine can interact with other medications, including other antihypertensive drugs, diuretics, and beta blockers. These interactions can increase the risk of side effects or reduce the effectiveness of the medications.

See Also

• Antihypertensive drug
• Vasodilator
• Hypertension