Cafedrine

Cafedrine is a cardiovascular drug that is often used in combination with theodrenaline to achieve a balance between its stimulatory and relaxant effects. It is primarily used in the treatment of low blood pressure, particularly in cases of anesthesia-induced hypotension.

Pharmacology

Cafedrine is a mixed adrenergic agonist that primarily acts on alpha-1 adrenergic receptors. It also has some activity at beta adrenergic receptors, although this is less pronounced. The drug's primary effect is to increase blood pressure by causing vasoconstriction and increasing cardiac output.

Clinical Use

Cafedrine is most commonly used in combination with theodrenaline, a non-selective beta adrenergic agonist. This combination is known as Akrinor and is primarily used to treat hypotension during anesthesia. The theodrenaline component of Akrinor serves to counteract the vasoconstrictive effects of cafedrine, leading to a balanced increase in blood pressure.

Side Effects

Like all drugs, cafedrine can cause side effects. These may include tachycardia, hypertension, and palpitations. In rare cases, cafedrine can cause severe hypertensive crisis.

See Also

• Theodrenaline
• Akrinor
• Adrenergic agonist
• Hypotension

Cafedrine Resources
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