Calu-3

Calu-3 is a cell line derived from human lung cancer cells. It is commonly used in biomedical research to study lung diseases, drug delivery, and the biology of lung cancer.

History

The Calu-3 cell line was first established in 1975 from a 25-year-old Caucasian male with a well-differentiated adenocarcinoma of the lung. The cells were derived from a metastatic site in the pleural effusion.

Characteristics

Calu-3 cells are epithelial and have a high level of mucin production, which is characteristic of lung adenocarcinoma. They also express epidermal growth factor receptor (EGFR), which is often overexpressed in lung cancer and is a target for many cancer drugs.

Use in Research

Calu-3 cells are used in a variety of research applications. They are often used to study the biology of lung cancer, including the role of EGFR in cancer progression and the effects of various cancer drugs. They are also used to study drug delivery to the lungs, as they can be grown in a layer on a membrane to mimic the lining of the lungs. This allows researchers to test how well drugs can penetrate this layer and reach the underlying cells.

References

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