Chagas disease

Error creating thumbnail:

An acute Chagas disease infection with swelling of the right eye (Romaña's sign)

Definition

Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by the protozoa Trypanosoma cruzi.

Error creating thumbnail:

Triatoma

History

Chagas disease is named after the Brazilian physician Carlos Chagas, who discovered the disease in 1909.

Cause

It is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors and is found only in the Americas (mainly, in rural areas of Latin America where poverty is widespread).

Other names

Chagas disease (T. cruzi infection) is also referred to as American trypanosomiasis.

[[File:Heart pathology Chagas disease.JPG|thumb|Large scale anatomy of a heart damaged by chronic Chagas disease – see also: [[:Image:Heart

Pathophysiology

• Chagas disease is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors that are found only in the Americas (mainly, in rural areas of Latin America where poverty is widespread). Chagas disease (T. cruzi infection) is also referred to as American trypanosomiasis.
• It is estimated that as many as 8 million people in Mexico, Central America, and South America have Chagas disease, most of whom do not know they are infected. If untreated, infection is lifelong and can be life threatening.
• The impact of Chagas disease is not limited to only rural areas of Latin America in which vectorborne transmission (diseases transmitted by insects) occurs.
• Large-scale population movements from rural to urban areas of Latin America and to other regions of the world have increased the geographic distribution and changed the epidemiology of Chagas disease.
• In the United States and in other regions where Chagas disease is now found but is not endemic, control strategies should focus on preventing transmission from blood transfusion, organ transplantation, and mother-to-baby (congenital transmission).

Error creating thumbnail:

Rhodnius prolixus is the principal vector in Colombia, Venezuela, Guatemala, Honduras, and some parts of Nicaragua and El Salvador

Transmission

• People can become infected in several ways.
• In areas where Chagas disease is common, the main way is through vector borne transmission.
• The insect vectors are called triatomine bugs.

These blood-sucking bugs get infected with T. cruzi by biting an infected animal or person.

• Once infected, the bugs pass the parasites in their feces.
• The bugs are found in houses made from materials such as mud, adobe, straw, and palm thatch.
• During the day, the bugs hide in crevices in the walls and roofs.
• During the night, when the inhabitants are sleeping, the bugs emerge.
• Because they tend to bite people’s faces, triatomine bugs are also known as “kissing bugs”.
• After they bite and ingest blood, they defecate (poop) on the person.

The person can become infected if T. cruzi parasites in the bug feces enter the body through mucous membranes or breaks in the skin.

• The unsuspecting, sleeping person may accidentally scratch or rub the feces into the bite wound, eyes, or mouth.

Error creating thumbnail:

Awareness and prevention campaign poster in Cayenne, French Guiana, 2008

Other means of transmission

• Congenital transmission (from a pregnant woman to her baby);
• Blood transfusions;
• Organ transplantation;
• Consumption of uncooked food that is contaminated with feces (poop) from infected triatomine bugs; and
• Accidental laboratory exposure.
• It is generally considered safe to breastfeed even if the mother has Chagas disease except when the nipples are cracked.
• Chagas disease is not transmitted from person-to-person like a cold or the flu or through casual contact with infected people or animals.

Chagas disease in Latin America (endemic zones)

Family members

• Could have become infected the same way that you did, for example, by vectorborne transmission;
• Are your children and were born after you were infected; or if
• There are other reasons to think that they might have Chagas disease.
• In what parts of the world is Chagas disease found?
• People who have Chagas disease can be found anywhere in the world.

Error creating thumbnail:

Chagas megaesophagus

Signs and symptoms

Much of the clinical information about Chagas disease comes from experience with people who became infected as children through contact with triatomines. The severity and course of an individual infection can vary based on a number of factors, including the age at which a person became infected, the way in which a person acquired the infection, or the particular strain of the T. cruzi parasite.

Phases

There are two phases of Chagas disease: the acute phase and the chronic phase. Both phases can be symptom free or life threatening.

Error creating thumbnail:

Carlos Chagas, in his laboratory at Instituto Oswaldo Cruz

Romaña’s sign, the swelling of the child’s eyelid, is a marker of acute Chagas disease. Swelling is due to Trypanosoma cruzi infecting the eyelid when bug feces are accidentally rubbed into the eye, or because the bite wound was on the same side of the child’s face as the swelling. Credit: WHO/TDR

Acute phase: During this phase, which lasts for the first few weeks or months infection, a person may have no symptoms or mild ones, such as fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, and vomiting. Because these symptoms are similar to those of other illnesses, most people do not know their illness is from infection with the T. cruzi parasite.

Other signs:

• Mild enlargement of the liver or spleen, swollen glands, or swelling at the site of the bite (called a chagoma), where the parasite entered the body.
• Some people with acute phase infection may have swelling of the eyelids on the side of the face near the bite wound or where the bug poop was accidentally rubbed into the eye, called Romaña’s sign.
• Even if a person develops symptoms during the acute phase, they usually feel well within a few weeks or months but if the person is not treated with antiparasitic medication, the infection remains in the body.
• Rarely, young children (less than 5%) die from severe inflammation and infection of the heart muscle (myocarditis) or brain (meningoencephalitis).
• The acute phase also can be severe in people with weakened immune systems, such as patients taking chemotherapy or those with advanced HIV infection.

Chronic phase: During this phase, which can last for decades or even for the entirety of someone’s lifetime, most people have no symptoms. Approximately 20–30 percent of infected people develop

• Cardiac complications, which can include an enlarged heart, heart failure, altered heart rate or rhythm, and cardiac arrest (sudden death); and/or
• Gastrointestinal complications, which can include an enlarged esophagus (megaesophagus) or colon (megacolon) and can lead to difficulties with eating or pooping.

Diagnosis

• Chagas disease is diagnosed by blood tests.
• If you are found to have Chagas disease, you should have a heart tracing test (electrocardiogram), even if you feel fine.
• You might be referred to a specialist for more tests and for treatment.

Treatment

• Two approaches to therapy, that can be life-saving include:
• Antiparasitic treatment, to kill the parasite; and
• Symptomatic treatment, to manage the symptoms and signs of infection.
• Antiparasitic treatment is most effective early in the course of infection but is not limited to cases in the acute phase. In the United States, there are two types of treatments available.
• Benznidazole is approved by FDA for use in children 2–12 years of age
• Nifurtimox is not currently FDA approved and is available under an investigational protocol from CDC.
• Symptomatic treatment may help people who have cardiac or gastrointestinal problems from Chagas disease.

Travelling

• No drugs or vaccines for preventing infection are currently available.
• Travelers who sleep indoors, in well-constructed facilities (for example, air-conditioned or screened hotel rooms), are at low risk for exposure to infected triatomine bugs that usually live in poor-quality dwellings and are most active at night.
• Preventive measures include spraying infested dwellings with long-lasting insecticides, using bed nets treated with long-lasting insecticides, wearing protective clothing, and applying insect repellent to exposed skin.
• Travelers should observe food and beverage precautions and avoid consuming salads, uncooked vegetables, unpeeled fruits, and unpasteurized fruit juices.
• In areas of Mexico, Central America, and South America, where the Trypanosoma cruzi parasite is present in triatomine bugs, improved housing and spraying insecticide inside housing to eliminate the bugs has significantly decreased the spread of Chagas disease. Screening of blood donations for Chagas is another important public health tool to help prevent spreading the disease through blood transfusions. Early detection and treatment of new cases, including mother-to-baby (congenital) cases, will also help reduce the burden of disease.
• In the United States and in other regions where Chagas disease is now found but is not widespread, control strategies are focused on preventing transmission from blood transfusion, organ transplantation, and mother-to-baby.

Chagas disease Resources
Latest articles Most recent articles Ongoing trials	Wikipedia