Collecting duct carcinoma

From WikiMD's Wellness Encyclopedia


Collecting duct carcinoma in computed tomography

Collecting duct carcinoma (CDC) is a type of kidney cancer that originates in the papillary duct of the kidney. It is rare, accounting for 1-3% of all kidney cancers.[1] It is also recently described; a 2002 review found just 40 case reports worldwide.[2] Previously, due to its location, CDC was commonly diagnosed as renal cell carcinoma or a subtype of renal cell carcinoma.[3] However, CDC does not respond well to chemotherapy drugs used for renal cell carcinoma, and progresses and spreads more quickly.

Signs and symptoms[edit | edit source]

Signs and symptoms are as for kidney cancer.

Histology[edit | edit source]

Histologic examination of collecting duct carcinoma demonstrates an infiltrative lesion with tubulopapillary, irregular channels lined by high grade hobnail cells with marked desmoplastic response and brisk neutrophilic infiltrate.

Treatment[edit | edit source]


History[edit | edit source]

CDC was thought to be renal cell carcinoma, until "recently developed techniques of lectin histochemistry" helped forward knowledge of kidney duct cancers.[4]

References[edit | edit source]

External links[edit | edit source]

Classification
External resources

Contributors: Prab R. Tumpati, MD