Collecting duct carcinoma
Collecting duct carcinoma (CDC) is a type of kidney cancer that originates in the papillary duct of the kidney. It is rare, accounting for 1-3% of all kidney cancers.[1] It is also recently described; a 2002 review found just 40 case reports worldwide.[2] Previously, due to its location, CDC was commonly diagnosed as renal cell carcinoma or a subtype of renal cell carcinoma.[3] However, CDC does not respond well to chemotherapy drugs used for renal cell carcinoma, and progresses and spreads more quickly.
Signs and symptoms[edit | edit source]
Signs and symptoms are as for kidney cancer.
Histology[edit | edit source]
Histologic examination of collecting duct carcinoma demonstrates an infiltrative lesion with tubulopapillary, irregular channels lined by high grade hobnail cells with marked desmoplastic response and brisk neutrophilic infiltrate.
Treatment[edit | edit source]
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History[edit | edit source]
CDC was thought to be renal cell carcinoma, until "recently developed techniques of lectin histochemistry" helped forward knowledge of kidney duct cancers.[4]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
