Cytomegalic inclusion body disease

Cytomegalic inclusion body disease (CIBD) is a viral infection caused by the cytomegalovirus (CMV), a member of the Herpesviridae family. This disease is characterized by the presence of large cells with intranuclear and intracytoplasmic inclusions, which are indicative of CMV infection. CIBD primarily affects newborns and immunocompromised individuals, such as those with HIV/AIDS or undergoing organ transplantation.

Pathophysiology

Cytomegalovirus is a double-stranded DNA virus that can infect a variety of cell types, including epithelial cells, endothelial cells, fibroblasts, smooth muscle cells, and white blood cells. Once inside the host cell, CMV can remain latent and reactivate under certain conditions, particularly when the host's immune system is compromised.

Clinical Manifestations

The clinical manifestations of CIBD vary depending on the age and immune status of the patient. In newborns, congenital CMV infection can lead to a range of symptoms, including jaundice, hepatosplenomegaly, microcephaly, sensorineural hearing loss, and developmental delays. In immunocompromised individuals, CIBD can cause severe complications such as pneumonia, retinitis, colitis, and encephalitis.

Diagnosis

Diagnosis of CIBD is typically made through the detection of CMV in bodily fluids or tissues. Common diagnostic methods include polymerase chain reaction (PCR), serology, and histopathology. The presence of characteristic cytomegalic cells with inclusion bodies in tissue samples is a hallmark of the disease.

Treatment

Treatment of CIBD involves the use of antiviral medications such as ganciclovir, valganciclovir, foscarnet, and cidofovir. These medications can help to control the infection and reduce the severity of symptoms. In some cases, immunoglobulin therapy may also be used to boost the immune response.

Prevention

Preventive measures for CIBD include good hygiene practices, such as regular handwashing, especially for pregnant women and individuals who are immunocompromised. In healthcare settings, strict adherence to infection control protocols is essential to prevent the spread of CMV.

Related Pages

• Cytomegalovirus
• Herpesviridae
• Immunocompromised host
• Congenital infection
• Antiviral drug