Cytomegalovirus colitis

Cytomegalovirus Colitis (CMV Colitis) is an inflammation of the colon caused by infection with the Cytomegalovirus (CMV). CMV is a type of herpesvirus, and it is a common virus affecting people of all ages worldwide. While the virus is usually dormant in the body, it can become active and cause disease in individuals with weakened immune systems, such as those with HIV/AIDS, organ transplant recipients, or patients receiving chemotherapy.

Symptoms

Symptoms of CMV colitis can vary but often include:

• Diarrhea
• Abdominal pain
• Fever
• Weight loss
• Rectal bleeding

Diagnosis

Diagnosis of CMV colitis involves a combination of clinical evaluation, laboratory tests, and imaging studies. Key diagnostic methods include:

• Serology tests to detect CMV antibodies
• Polymerase Chain Reaction (PCR) tests to detect CMV DNA
• Colonoscopy with biopsy for histopathological examination

Treatment

Treatment for CMV colitis typically involves antiviral therapy to reduce CMV viral load. Common antiviral medications include:

• Ganciclovir
• Valganciclovir
• Foscarnet
• Cidofovir

In addition to antiviral therapy, supportive care such as hydration and nutritional support may be necessary.

Prevention

Prevention of CMV colitis primarily focuses on reducing the risk of CMV infection and reactivation, especially in immunocompromised individuals. Strategies include:

• Regular monitoring for CMV in high-risk patients
• Prophylactic antiviral therapy in certain cases
• Practicing good hygiene to reduce the risk of CMV transmission

Epidemiology

CMV colitis is most commonly seen in individuals with compromised immune systems. The prevalence of CMV infection in the general population is high, but symptomatic colitis is relatively rare in those with a healthy immune system.

Complications

If left untreated, CMV colitis can lead to severe complications such as:

• Colonic perforation
• Severe bleeding
• Systemic CMV infection

See Also

• Cytomegalovirus
• Colitis
• Immunocompromised Host
• Antiviral Drug