Delta sleep-inducing peptide

Delta sleep-inducing peptide (DSIP), first discovered in 1974, is a neuropeptide that induces sleep and modulates dreaming. It is a non-standard amino acid sequence of nine residues that is produced in many areas of the body including the brain and gut.

Discovery

DSIP was first discovered in the cerebral venous blood of rabbits in a state of sleep. It was isolated from the cerebral ischemic rabbits during sleep. The peptide is thought to be involved in the regulation of sleep patterns.

Structure

DSIP is a small peptide, consisting of nine amino acids with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. The structure of DSIP is unique among all known peptides.

Function

DSIP has been found to have a wide variety of effects in the body. It has been shown to induce sleep, normalize blood pressure, decrease motor activity, and regulate the body's response to stress. It also has an effect on the release of luteinizing hormone and the release of somatostatin.

Clinical significance

DSIP has potential therapeutic uses in the treatment of sleep disorders, including insomnia. It may also have uses in the treatment of certain types of cancer, as it has been shown to inhibit the growth of certain cancer cells. However, more research is needed to fully understand the potential uses of DSIP in medicine.

See also

• Sleep
• Neuropeptide
• Insomnia
• Cancer