Dyslipidemia
(Redirected from Dyslipidemias)
Dyslipidemia, sometimes spelled as dyslipidaemia, refers to an abnormal amount of lipids (fats) in the blood. This can involve an elevation of total cholesterol, LDL cholesterol, and triglycerides, or a low HDL cholesterol level. Dyslipidemia is a primary contributor to atherosclerosis and, consequently, cardiovascular diseases like heart attacks and strokes. The disorder can be primary, stemming from genetic causes, or secondary, resulting from a variety of factors like diet, medications, or other medical conditions.
Types of Dyslipidemia[edit | edit source]
Dyslipidemias are classified based on the component of the lipids that are abnormal:
- Hypercholesterolemia: Elevated levels of cholesterol in the blood.
- Hypertriglyceridemia: Elevated levels of triglycerides.
- Combined hyperlipidemia: Elevated levels of cholesterol and triglycerides.
- Low HDL cholesterol: Reduced levels of HDL cholesterol, often associated with elevated triglycerides.
Causes[edit | edit source]
Dyslipidemia can arise from multiple factors, which can be broadly categorized as:
Primary (Genetic) Causes:
- Familial hypercholesterolemia
- Familial combined hyperlipidemia
- Familial hypertriglyceridemia
- Genetic deficiency of HDL
Secondary Causes:
- Diet high in saturated and trans fats
- Medications such as corticosteroids, beta-blockers, and antipsychotics
- Conditions like diabetes, hypothyroidism, and polycystic ovary syndrome (PCOS)
- Lifestyle factors including smoking and sedentary behavior
Symptoms and Diagnosis[edit | edit source]
While dyslipidemia itself doesn't produce symptoms, it can lead to atherosclerotic plaque buildup in the arteries, potentially culminating in cardiovascular complications. Diagnosis is generally through a blood test called a lipid profile or lipid panel.
Management and Treatment[edit | edit source]
Managing dyslipidemia often involves a two-pronged approach:
Lifestyle Modifications:
- Adopting a heart-healthy diet low in saturated and trans fats
- Engaging in regular physical activity
- Maintaining a healthy weight
- Avoiding tobacco products
Pharmacotherapy:
- Statins
- Fibrates
- Niacin
- Omega-3 fatty acid supplements
- PCSK9 inhibitors
- Bile acid sequestrants
Periodic monitoring of lipid levels, especially after initiating medications or significant lifestyle changes, is crucial.
Complications[edit | edit source]
If untreated or inadequately managed, dyslipidemia can contribute to:
Research and Future Outlook[edit | edit source]
Research into dyslipidemia is ongoing. Recent advancements have centered on understanding the genetic markers associated with the disease and the development of new drug treatments. With the advent of precision medicine, treatments tailored to an individual's genetic makeup may become more commonplace in the future. Additionally, there's growing interest in exploring the role of the gut microbiome in lipid metabolism and its potential implications for treating dyslipidemia.
See also[edit | edit source]
Dyslipidemia Resources | ||
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Contributors: Prab R. Tumpati, MD