FCGR2C

FCGR2C or Fc gamma receptor IIc is a protein that in humans is encoded by the FCGR2C gene. It is a member of the Fc gamma receptor family, which are cell surface receptors found on certain cells in the immune system. These receptors play a key role in the immune response, including the process of phagocytosis and the release of cytokines.

Structure[edit | edit source]

The FCGR2C protein is a low affinity receptor for the Fc region of immunoglobulin G (IgG). It is structurally similar to other Fc gamma receptors, consisting of two extracellular Ig-like domains, a transmembrane domain, and a cytoplasmic tail. The extracellular domains are responsible for binding to IgG, while the cytoplasmic tail is involved in signal transduction.

Function[edit | edit source]

FCGR2C is involved in a variety of immune responses. It can mediate phagocytosis, the process by which cells engulf and destroy foreign particles or pathogens. It can also trigger the release of cytokines, which are signaling molecules that regulate immune responses. In addition, FCGR2C can activate natural killer cells, a type of white blood cell that plays a key role in the body's defense against viruses and cancer.

Clinical significance[edit | edit source]

Mutations in the FCGR2C gene have been associated with susceptibility to autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus. In addition, variations in this gene may influence the severity of HIV infection and the progression to AIDS.

File:Fc gamma receptor IIc.png

Structure of the FCGR2C protein.