Ferriprox

Ferriprox is a medication used in the treatment of iron overload in patients with thalassemia when current chelation therapy is inadequate. It is also known by its generic name, deferiprone.

Mechanism of Action

Ferriprox is an iron chelator that binds to iron and removes it from the bloodstream. It works by binding to free iron in the bloodstream and forming a complex that is then excreted in the urine.

Indications

Ferriprox is indicated for the treatment of patients with thalassemia syndromes who have transfusional iron overload due to blood transfusions. It is used when current chelation therapy is inadequate.

Side Effects

Common side effects of Ferriprox include nausea, vomiting, abdominal pain, and joint pain. Serious side effects can include neutropenia and agranulocytosis.

Contraindications

Ferriprox is contraindicated in patients with known hypersensitivity to deferiprone or any component of the formulation. It is also contraindicated in patients with severe neutropenia or a history of agranulocytosis.

Drug Interactions

Ferriprox may interact with other medications, including other iron chelators. It is important to tell your doctor about all medications you are taking, including over-the-counter drugs and supplements.

Dosage and Administration

The recommended starting dose of Ferriprox is 25 mg/kg body weight three times per day, taken orally. The dose may be adjusted based on individual patient response and tolerability.

See Also

• Iron overload
• Thalassemia
• Iron chelator
• Neutropenia
• Agranulocytosis

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