Forbes–Albright syndrome
Forbes–Albright syndrome is a rare endocrine disorder characterized by the overproduction of prolactin due to a pituitary gland tumor, leading to galactorrhea, amenorrhea, and infertility in women. The syndrome was first described by Fuller Albright and Kenneth Forbes in 1939.
Symptoms and Signs[edit | edit source]
The primary symptoms of Forbes–Albright syndrome are galactorrhea, amenorrhea, and infertility. Galactorrhea refers to the spontaneous flow of milk from the breast, unrelated to childbirth or nursing. Amenorrhea is the absence of menstruation. Infertility is the inability to conceive a child.
Causes[edit | edit source]
Forbes–Albright syndrome is caused by a benign tumor of the pituitary gland, known as a prolactinoma. This tumor overproduces the hormone prolactin, which is responsible for milk production in women. The overproduction of prolactin leads to the symptoms of the syndrome.
Diagnosis[edit | edit source]
Diagnosis of Forbes–Albright syndrome is based on the presence of the characteristic symptoms, as well as blood tests showing elevated levels of prolactin. Imaging studies, such as MRI or CT scan, may be used to visualize the pituitary tumor.
Treatment[edit | edit source]
Treatment for Forbes–Albright syndrome typically involves medication to reduce the production of prolactin and shrink the tumor. In some cases, surgery may be necessary to remove the tumor.
Prognosis[edit | edit source]
With appropriate treatment, the prognosis for individuals with Forbes–Albright syndrome is generally good. Most individuals are able to manage their symptoms and lead normal lives.
See Also[edit | edit source]
NIH genetic and rare disease info[edit source]
Forbes–Albright syndrome is a rare disease.
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