Forbes–Albright syndrome

Forbes–Albright syndrome is a rare endocrine disorder characterized by the overproduction of prolactin due to a pituitary gland tumor, leading to galactorrhea, amenorrhea, and infertility in women. The syndrome was first described by Fuller Albright and Kenneth Forbes in 1939.

Symptoms and Signs

The primary symptoms of Forbes–Albright syndrome are galactorrhea, amenorrhea, and infertility. Galactorrhea refers to the spontaneous flow of milk from the breast, unrelated to childbirth or nursing. Amenorrhea is the absence of menstruation. Infertility is the inability to conceive a child.

Causes

Forbes–Albright syndrome is caused by a benign tumor of the pituitary gland, known as a prolactinoma. This tumor overproduces the hormone prolactin, which is responsible for milk production in women. The overproduction of prolactin leads to the symptoms of the syndrome.

Diagnosis

Diagnosis of Forbes–Albright syndrome is based on the presence of the characteristic symptoms, as well as blood tests showing elevated levels of prolactin. Imaging studies, such as MRI or CT scan, may be used to visualize the pituitary tumor.

Treatment

Treatment for Forbes–Albright syndrome typically involves medication to reduce the production of prolactin and shrink the tumor. In some cases, surgery may be necessary to remove the tumor.

Prognosis

With appropriate treatment, the prognosis for individuals with Forbes–Albright syndrome is generally good. Most individuals are able to manage their symptoms and lead normal lives.

See Also

• Pituitary gland
• Prolactin
• Prolactinoma
• Galactorrhea
• Amenorrhea
• Infertility

NIH genetic and rare disease info

• NIH info on Forbes–Albright syndrome

Forbes–Albright syndrome is a rare disease.

Forbes–Albright syndrome Resources
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