Fosdagrocorat

From WikiMD's Wellness Encyclopedia

Fosdagrocorat (also known as PF-04171327) is a glucocorticoid prodrug that was under development by Pfizer for the treatment of rheumatoid arthritis. It is a selective glucocorticoid receptor modulator (SGRM) that was designed to provide the anti-inflammatory benefits of glucocorticoids without the associated side effects.

Chemistry[edit | edit source]

Fosdagrocorat is a prodrug of dagrocorat, a non-steroidal glucocorticoid receptor agonist. The prodrug is converted to the active drug in the body by the action of esterase enzymes. The chemical structure of fosdagrocorat includes a phosphonate group, which is responsible for its prodrug properties.

Pharmacology[edit | edit source]

The pharmacological action of fosdagrocorat is based on its conversion to dagrocorat, which binds to the glucocorticoid receptor and modulates its activity. This results in a reduction of inflammation and immune response, which are key factors in the pathogenesis of rheumatoid arthritis.

Clinical trials[edit | edit source]

Fosdagrocorat was evaluated in several clinical trials for the treatment of rheumatoid arthritis. The results showed that the drug was effective in reducing the symptoms of the disease, but its development was discontinued due to concerns about its safety profile.

See also[edit | edit source]

References[edit | edit source]



WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD