Fructoselysine-6-kinase

Fructoselysine-6-kinase is an enzyme that catalyzes the phosphorylation of fructoselysine, a non-proteinogenic amino acid. This enzyme plays a crucial role in the metabolism of advanced glycation end-products (AGEs), which are implicated in various pathological conditions, including diabetes and aging.

Function

Fructoselysine-6-kinase is involved in the metabolic pathway that detoxifies fructoselysine. This enzyme catalyzes the transfer of a phosphate group from adenosine triphosphate (ATP) to the 6-position of fructoselysine, producing fructoselysine-6-phosphate and adenosine diphosphate (ADP).

Clinical significance

The accumulation of fructoselysine and other AGEs is associated with various pathological conditions. In diabetes, high blood glucose levels lead to the formation of fructoselysine in proteins, which can cause tissue damage and complications such as retinopathy, nephropathy, and neuropathy. The activity of fructoselysine-6-kinase may therefore have therapeutic implications for the treatment of diabetes and other AGE-related diseases.

See also

• Fructoselysine
• Advanced glycation end-product
• Phosphorylation
• Diabetes