Granulosa cell tumor

Granulosa cell tumor is a type of ovarian cancer that originates from the granulosa cells in the ovary. These tumors are part of a larger group of sex cord-stromal tumors and can be further classified into adult and juvenile types based on their clinical and histopathological characteristics.

Epidemiology

Granulosa cell tumors are rare and account for approximately 2% of all ovarian tumors. The adult type is more common and usually occurs in postmenopausal women, while the juvenile type is less common and tends to occur in infants and young girls.

Symptoms

The symptoms of granulosa cell tumor can vary and may include abdominal pain, bloating, menstrual irregularities, and postmenopausal bleeding. Some patients may also present with sexual precocity due to the tumor's ability to produce estrogen.

Diagnosis

The diagnosis of granulosa cell tumor is often made based on the patient's clinical presentation, imaging studies, and histopathological examination of the tumor. Blood tests may also be performed to measure levels of inhibin, a hormone that is often elevated in patients with granulosa cell tumors.

Treatment

The treatment of granulosa cell tumor typically involves surgery to remove the tumor. This may be followed by chemotherapy or radiation therapy depending on the stage of the disease. The prognosis for patients with granulosa cell tumor is generally good, especially if the tumor is detected early and completely removed.

See also

• Ovarian cancer
• Sex cord-stromal tumor
• Inhibin

Granulosa cell tumor Resources
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