HIST2H3A
HIST2H3A is a gene that encodes the histone H3.2 protein in humans. Histones are proteins that package and order the DNA into structural units called nucleosomes. They play a central role in gene regulation.
Function[edit | edit source]
The HIST2H3A gene is part of the histone H3 family, which includes several histones that make up the core of the nucleosome. Histone proteins H2A, H2B, H3, and H4 are the core histones, while histone H1 is the linker histone.
The HIST2H3A gene provides instructions for making a protein called histone H3.2. This protein is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells.
Clinical significance[edit | edit source]
Mutations in the HIST2H3A gene have been associated with a rare type of brain tumor called diffuse intrinsic pontine glioma (DIPG).
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
