HOXD11
HOXD11 is a gene that belongs to the homeobox family of genes. The protein encoded by this gene is a transcription factor that plays a crucial role in the development of the limbs and genitalia in mammals.
Function[edit | edit source]
The HOXD11 gene is part of the HOXD gene cluster, which is one of four clusters of homeobox genes. These genes are highly conserved across species and play a key role in morphogenesis and development. The HOXD11 gene, in particular, is involved in the formation and differentiation of the limbs and genitalia. It is expressed in the posterior part of the developing limb bud, where it helps to determine the identity of the digits.
Clinical significance[edit | edit source]
Mutations in the HOXD11 gene have been associated with several congenital disorders. These include hand-foot-genital syndrome, which is characterized by limb and genital abnormalities, and synpolydactyly, a condition that involves the fusion of digits and the presence of extra digits.
See also[edit | edit source]
References[edit | edit source]
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