TPO
TPO or Thyroid Peroxidase is an enzyme expressed mainly in the thyroid where it plays a key role in the production of thyroid hormones. A thyroid is a butterfly-shaped gland located in the neck, and it produces hormones that regulate the body's metabolic rate, heart and digestive function, muscle control, brain development, and bone maintenance.
TPO is a membrane-bound glycoprotein which, like all peroxidases, contains heme. Its main function is to catalyze the biosynthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Function[edit | edit source]
TPO is involved in the iodination of tyrosyl residues in thyroglobulin (Tg) to form monoiodotyrosine (MIT) and diiodotyrosine (DIT). It also catalyzes the coupling of these iodotyrosyl residues to form T4 and T3, which are then released into the bloodstream.
Clinical Significance[edit | edit source]
TPO is the major autoantigen of the thyroid. Autoantibodies to TPO (TPOAb) are found in nearly all patients with Hashimoto's thyroiditis and in the majority of patients with Graves' disease, both of which are autoimmune diseases of the thyroid.
TPOAb are also found in other autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and type 1 diabetes.
See Also[edit | edit source]
| TPO Resources | |
|---|---|
|
 |
References[edit | edit source]
External Links[edit | edit source]
0
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
