Hand–Schüller–Christian disease

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Hand–Schüller–Christian disease is associated with multifocal Langerhans cell histiocytosis.

It is associated with a triad of exophthalmos, lytic bone lesions (often in the skull), and diabetes insipidus (from pituitary stalk infiltration).[1]

It is named for the American pediatrician Alfred Hand Jr.,[2] the Austrian neurologist and radiologist Arthur Schüller,[3] and the American internist Henry Asbury Christian,[4] who described it in 1893,[5] 1915/16[6] and 1919[7]

See also[edit | edit source]

References[edit | edit source]

  1. "Alfred Hand Jr".
  2. Schindler E. Arthur Schüller: pioneer of neuroradiology. AJNR Am J Neuroradiol 1997; 18: 1297–1302
  3. Anonymous. Henry Asbury Christian (1876 – 1951). N Engl J Med 1951; 245: 912–913
  4. A. Hand. Polyuria and tuberculosis. Proceedings of the Pathological Society of Philadelphia, 1893, 16: 282-284. Archives of Pediatrics, New York, 1893: 10: 673-675.
  5. A. Schüller. Über eigenartige Schädeldefekte im Jugendalter («Landkartenschädel»). Fortschritte auf dem Gebiete der Röntgenstrahlen, 1915-1916; 23: 12-18.
  6. H. Christian. Defects in membranous bones, exophthalmos, and diabetes insipidus; an unusual syndrome of dyspituitarism. In: Contributions to medical and biological research, dedicated to Sir William Osler. New York, P. B. Hoeber, 1919, 1: 390-401. Medical Clinics of North America, Philadelphia, PA., 1920; 3: 849-871.

External links[edit | edit source]

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