Hay–Wells syndrome
Hay–Wells syndrome (also known as AEC syndrome) is a rare genetic disorder characterized by anodontia or hypodontia, ectodermal dysplasia, and cleft lip/palate. The syndrome is caused by mutations in the TP63 gene.
Symptoms[edit | edit source]
The symptoms of Hay–Wells syndrome can vary greatly from person to person. However, common symptoms include:
- Anodontia or hypodontia: This refers to the absence or underdevelopment of teeth.
- Ectodermal dysplasia: This is a group of conditions in which the normal development of the ectodermal tissues (including the skin, hair, nails, and sweat glands) is disturbed.
- Cleft lip/palate: This is a split in the upper lip and/or roof of the mouth that is present from birth.
Causes[edit | edit source]
Hay–Wells syndrome is caused by mutations in the TP63 gene. This gene provides instructions for making a protein that is crucial for the development and maintenance of various tissues, including the skin, hair, teeth, and sweat glands.
Diagnosis[edit | edit source]
The diagnosis of Hay–Wells syndrome is typically based on the presence of characteristic signs and symptoms. Genetic testing can confirm the diagnosis.
Treatment[edit | edit source]
There is currently no cure for Hay–Wells syndrome. Treatment is symptomatic and supportive, and may include dental implants for missing teeth, surgery for cleft lip/palate, and various interventions to manage the symptoms of ectodermal dysplasia.
See also[edit | edit source]
Hay–Wells syndrome Resources | ||
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