Hexestrol dipropionate

Hexestrol diphosphate is a synthetic, nonsteroidal estrogen that was previously used in medicine but has since been discontinued. It is a derivative of diethylstilbestrol and is related to other synthetic estrogens like dienestrol and chlorotrianisene.

History

Hexestrol diphosphate was first synthesized in the 1930s, along with other synthetic estrogens like diethylstilbestrol and dienestrol. These compounds were developed as a result of research into the structure-activity relationships of the estrogens.

Medical uses

Hexestrol diphosphate was used in the treatment of menopausal symptoms, prostate cancer, and certain breast cancers. However, it has been discontinued and is no longer available for medical use.

Pharmacology

As an estrogen, hexestrol diphosphate binds to and activates the estrogen receptor, a type of nuclear receptor that is activated by the hormone estrogen. This results in a change in gene expression which can result in a change in cellular function.

Side effects

Like other estrogens, hexestrol diphosphate can cause a number of side effects, including nausea, vomiting, breast tenderness, and menstrual irregularities. It can also increase the risk of certain types of cancer, including breast cancer and endometrial cancer.

See also

• List of estrogens
• List of discontinued drugs