Hypergonadotropic

Hypergonadotropic hypogonadism (or primary hypogonadism) refers to the decreased function of the gonads, the primary reproductive organs, due to issues arising within the gonads themselves. This condition is characterized by high levels of gonadotropins, hormones that stimulate the gonads, including follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

Causes

Hypergonadotropic hypogonadism can be caused by a variety of conditions, including Turner syndrome, Klinefelter syndrome, and gonadal dysgenesis. Other causes can include autoimmune disorders, infections, radiation therapy, and chemotherapy.

Symptoms

The symptoms of hypergonadotropic hypogonadism can vary depending on the underlying cause. Common symptoms can include delayed or absent puberty, infertility, and low levels of sex hormones. In females, this can lead to amenorrhea (absence of menstruation), and in males, it can lead to impotence.

Diagnosis

Diagnosis of hypergonadotropic hypogonadism typically involves blood tests to measure levels of FSH, LH, and sex hormones. Imaging tests, such as ultrasound, may also be used to examine the gonads.

Treatment

Treatment for hypergonadotropic hypogonadism typically involves hormone replacement therapy to restore normal hormone levels. In some cases, surgery may be required to remove damaged or non-functioning gonads.

See also

• Hypogonadism
• Hypogonadotropic hypogonadism
• Gonad

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