Irisin

Irisin is a hormone produced by muscle cells in response to exercise. It is named after the Greek goddess Iris, due to its ability to deliver messages to body tissues. Irisin is believed to have several beneficial effects on human health, including the regulation of body weight, glucose metabolism, and heart health.

Discovery

Irisin was discovered in 2012 by a team of researchers led by Bruce Spiegelman at Dana-Farber Cancer Institute. The discovery was based on the observation that exercise increases the expression of a gene called FNDC5 in muscle cells. The researchers found that FNDC5 is cleaved and secreted as irisin, which then circulates in the blood and acts on other tissues.

Function

Irisin is secreted by muscle cells during exercise and acts on white adipose tissue, converting it into brown adipose tissue. This process, known as "browning", increases energy expenditure and improves metabolic health. Irisin also has direct effects on the heart and brain, promoting cardioprotection and neuroprotection.

Clinical significance

Studies have suggested that irisin could be used as a therapeutic agent for obesity, diabetes, and cardiovascular disease. However, more research is needed to fully understand the potential of this hormone in medicine.

See also

• Exercise physiology
• Metabolism
• Obesity
• Diabetes mellitus
• Cardiovascular disease

References

Irisin Resources
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