Late-onset hypogonadism

Late-onset hypogonadism is a medical condition in men characterized by the decline in testosterone production with aging. It is also known as andropause or male menopause.

Definition

Late-onset hypogonadism is defined as a syndrome in men associated with advancing age, characterized by particular symptoms and a deficiency in serum testosterone levels. The European Male Aging Study has defined late-onset hypogonadism as a biochemical syndrome associated with aging and characterized by a deficiency in serum testosterone levels below the young healthy adult male reference range.

Symptoms

Symptoms of late-onset hypogonadism include decreased libido, erectile dysfunction, reduced muscle mass and strength, increased body fat, decreased bone mineral density, and anemia. Other symptoms may include reduced vitality, depressed mood, and cognitive decline.

Causes

The primary cause of late-onset hypogonadism is aging. Other factors that may contribute to the development of this condition include obesity, metabolic syndrome, and type 2 diabetes.

Diagnosis

Diagnosis of late-onset hypogonadism involves the measurement of serum testosterone levels. The Endocrine Society recommends making a diagnosis of late-onset hypogonadism only in men with consistent symptoms and signs and unequivocally low serum testosterone levels.

Treatment

Treatment for late-onset hypogonadism is typically with testosterone replacement therapy. This therapy can help to alleviate symptoms and improve quality of life. However, it is not without risks and potential side effects, and should be considered carefully in consultation with a healthcare provider.

See also

• Testosterone
• Hypogonadism
• Andropause
• Male menopause
• Endocrine Society
• European Male Aging Study

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