Laurence H. Kedes

Photo of Larry Kedes at University of Pennsylvania, 2014

Laurence H. Kedes is a prominent American physician and scientist known for his significant contributions to the field of molecular biology and genetics. He has made notable advancements in understanding the regulation of gene expression and the molecular mechanisms underlying various human diseases.

Early Life and Education

Laurence H. Kedes was born in New York City. He pursued his undergraduate studies at Harvard University, where he earned a Bachelor of Arts degree in Biochemistry. He then attended Columbia University College of Physicians and Surgeons, where he obtained his Doctor of Medicine (M.D.) degree.

Career

After completing his medical degree, Kedes undertook postdoctoral research at the National Institutes of Health (NIH) in the laboratory of Dr. Marshall Nirenberg, a Nobel laureate. During his time at the NIH, Kedes focused on the genetic code and the mechanisms of protein synthesis.

Kedes later joined the faculty at Stanford University School of Medicine, where he became a professor of biochemistry and genetics. His research at Stanford centered on the regulation of gene expression in eukaryotic cells, particularly the role of transcription factors and promoter regions in gene regulation.

Research Contributions

Laurence H. Kedes is renowned for his pioneering work on the alpha-skeletal actin gene, which plays a crucial role in muscle development and function. His research has provided valuable insights into the molecular basis of muscle diseases such as muscular dystrophy and cardiomyopathy.

Kedes has also contributed to the understanding of oncogenes and tumor suppressor genes, shedding light on the molecular pathways involved in cancer development and progression. His work has implications for the development of targeted therapies for various types of cancer.

Awards and Honors

Throughout his career, Laurence H. Kedes has received numerous awards and honors for his contributions to biomedical research. He is a member of several prestigious organizations, including the National Academy of Sciences and the American Academy of Arts and Sciences.

Personal Life

Laurence H. Kedes is married and has two children. He continues to be active in the scientific community, mentoring young researchers and contributing to various scientific advisory boards.

See Also

• Molecular biology
• Genetics
• Gene expression
• Muscular dystrophy
• Cancer research

External Links

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