Lymph node trabeculae

Lymph node trabeculae are small, beam-like structures found within lymph nodes, which are an integral part of the immune system. They provide structural support to the lymph node and help in the organization of lymphatic tissue.

Structure

Lymph node trabeculae originate from the capsule, a dense layer of connective tissue that surrounds each lymph node. They extend into the interior of the lymph node, dividing it into compartments. These trabeculae contain collagen fibers and fibroblasts, which are cells that produce collagen.

Function

The primary function of lymph node trabeculae is to provide structural support. They help maintain the shape of the lymph node and prevent it from collapsing. In addition, they serve as a pathway for lymphatic vessels and blood vessels, allowing these vessels to penetrate into the lymph node.

Trabeculae also play a role in the organization of lymphatic tissue. They separate the lymphoid tissue into different regions, each with a specific function in the immune response. For example, they separate the cortex, which contains B cells, from the medulla, which contains plasma cells and macrophages.

Clinical significance

Abnormalities in the structure or number of lymph node trabeculae can be indicative of certain diseases. For example, in lymphoma, a type of cancer that starts in the lymph nodes, the trabeculae may be destroyed or replaced by cancer cells. In tuberculosis, the trabeculae may become thickened and fibrotic.

Pathologists often examine the trabeculae when diagnosing these and other diseases. They may use techniques such as histology, the study of the microscopic structure of tissues, and immunohistochemistry, which involves staining tissues with antibodies to detect specific proteins.

See also

• Lymphatic system
• Lymph node
• Immune system