Lysergamides

Lysergamides are a class of compounds derived from lysergic acid, a substance found in various types of fungi, most notably the ergot fungus. They are known for their psychedelic properties and are used in both scientific research and recreational drug use.

History

The history of lysergamides dates back to the discovery of lysergic acid in the early 20th century. The most well-known lysergamide, LSD, was first synthesized in 1938 by Swiss chemist Albert Hofmann. Since then, many other lysergamides have been discovered and synthesized.

Chemistry

Lysergamides are derived from lysergic acid, which is composed of a bicyclic hexahydroindole fused to a bicyclic quinoline group (lysergic acid). Notable lysergamides include LSD, ALD-52, 1P-LSD, ETH-LAD, PRO-LAD, and AL-LAD.

Effects

The effects of lysergamides are primarily due to their action as serotonin receptor agonists. They can cause a wide range of effects, including altered thinking processes, closed- and open-eye visuals, synesthesia, an altered sense of time, and spiritual experiences. The effects can vary greatly depending on the specific compound and the dosage.

Legal Status

The legal status of lysergamides varies by country. In many countries, including the United States, they are classified as Schedule I drugs under the Controlled Substances Act. However, some lysergamides are legal to possess and use in certain countries.

Research

Research into lysergamides has been conducted for their potential therapeutic uses. Some studies suggest that they may be effective in treating a variety of conditions, including cluster headaches, end-of-life anxiety, and certain types of addiction.

See Also

• Psychedelic drug
• Psychedelic therapy
• Serotonergic psychedelic