Suprofen

A nonsteroidal anti-inflammatory drug

Suprofen

Suprofen is a nonsteroidal anti-inflammatory drug (NSAID) that was used primarily for its analgesic and anti-inflammatory properties. It is a member of the propionic acid class of NSAIDs, which also includes drugs like ibuprofen and naproxen.

Chemical Structure

Chemical structure of Suprofen

Suprofen is chemically known as (±)-2-(4-(2-thienylcarbonyl)phenyl)propionic acid. It features a thiophene ring, which is a sulfur-containing heterocycle, attached to a phenyl group, which is further connected to a propionic acid moiety.

Mechanism of Action

Suprofen works by inhibiting the cyclooxygenase (COX) enzymes, which are responsible for the conversion of arachidonic acid into prostaglandins. Prostaglandins are compounds that mediate inflammation, pain, and fever. By reducing the production of prostaglandins, suprofen alleviates symptoms of inflammation and pain.

Uses

Suprofen was primarily used for the relief of mild to moderate pain and inflammation. It was also used in ophthalmic formulations to prevent intraoperative miosis during cataract surgery.

Side Effects

Like other NSAIDs, suprofen can cause a range of side effects, including gastrointestinal issues such as gastritis, ulceration, and bleeding. It may also cause renal impairment and hypersensitivity reactions.

Withdrawal

Suprofen was withdrawn from the market due to concerns over its potential to cause nephrotoxicity, particularly in patients with pre-existing kidney conditions.

Related pages

• Nonsteroidal anti-inflammatory drug
• Ibuprofen
• Naproxen
• Cyclooxygenase