Mueller–Weiss syndrome

Mueller–Weiss syndrome (MWS), also known as Spontaneous Osteonecrosis of the Tarsal Navicular in Adults, is a rare, spontaneous osteonecrosis of the tarsal navicular in adults. It was first described by Mueller and Weiss in 1927.

Etiology

The exact cause of Mueller–Weiss syndrome is unknown. However, it is believed to be due to a combination of biomechanical and vascular factors. The navicular bone is subjected to high compressive forces, which may lead to stress fractures and subsequent osteonecrosis. Additionally, the blood supply to the navicular bone is precarious, which may contribute to the development of osteonecrosis.

Clinical Presentation

Patients with Mueller–Weiss syndrome typically present with chronic, midfoot pain that is exacerbated by weight-bearing activities. Physical examination may reveal swelling and tenderness over the navicular bone.

Diagnosis

The diagnosis of Mueller–Weiss syndrome is primarily based on clinical presentation and imaging studies. Radiography is typically the first imaging modality used. However, MRI is more sensitive and specific in detecting early changes of osteonecrosis.

Treatment

The treatment of Mueller–Weiss syndrome is primarily conservative and includes rest, NSAIDs, and orthotic devices. In refractory cases, surgical intervention may be required.

Prognosis

The prognosis of Mueller–Weiss syndrome is variable. Some patients may experience resolution of symptoms with conservative treatment, while others may require surgical intervention. Long-term outcomes are generally favorable with appropriate treatment.

See Also

• Osteonecrosis
• Tarsal navicular
• Radiography
• Magnetic Resonance Imaging

NIH genetic and rare disease info

• NIH info on Mueller–Weiss syndrome

Mueller–Weiss syndrome is a rare disease.

Mueller–Weiss syndrome Resources
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