NEURL2

NEURL2 is a gene that encodes a protein in humans. This protein is part of the E3 ubiquitin-protein ligase family, which plays a crucial role in the ubiquitin-proteasome system. The ubiquitin-proteasome system is responsible for the degradation of intracellular proteins, a process that is essential for various cellular functions such as cell cycle progression, signal transduction, and responses to oxidative stress.

Function

The protein encoded by the NEURL2 gene is a member of the neuralized E3 ubiquitin protein ligase family. Neuralized E3 ubiquitin protein ligases are involved in the process of ubiquitination, a post-translational modification of proteins that targets them for degradation by the proteasome. Ubiquitination is a crucial mechanism in the regulation of many cellular processes, including cell cycle progression, signal transduction, and responses to oxidative stress.

Clinical significance

While the specific clinical significance of NEURL2 is not yet fully understood, alterations in the ubiquitin-proteasome system have been implicated in a number of human diseases, including cancer, neurodegenerative diseases, and immune disorders. Further research is needed to elucidate the role of NEURL2 in these conditions.

Research

Research into the function and clinical significance of NEURL2 is ongoing. Current areas of investigation include the role of NEURL2 in cell cycle regulation, signal transduction, and the response to oxidative stress.

See also

• Ubiquitin
• Proteasome
• Ubiquitination
• E3 ubiquitin-protein ligase