NRIP1

NRIP1 (Nuclear Receptor Interacting Protein 1), also known as RIP140, is a protein that in humans is encoded by the NRIP1 gene. It is a nuclear protein that specifically interacts with the hormone-dependent activation function AF-2 of nuclear receptors.

Function

NRIP1 is known to regulate the transcriptional activity of various nuclear receptors by affecting their ligand-dependent transcription activity. It is involved in the regulation of several physiological processes, including metabolic and inflammatory responses, cell differentiation, and apoptosis.

Structure

The NRIP1 protein is composed of 1158 amino acids and has a molecular weight of approximately 130 kDa. It contains several leucine-rich repeats (LRRs) and a carboxy-terminal domain, which are essential for its interaction with nuclear receptors.

Clinical significance

Alterations in the expression of NRIP1 have been associated with various diseases, including obesity, type 2 diabetes, and cancer. In particular, overexpression of NRIP1 has been observed in several types of cancer, suggesting a potential role in tumorigenesis.

Research

Current research is focused on understanding the precise role of NRIP1 in disease progression and exploring its potential as a therapeutic target.

See also

• Nuclear receptor
• Transcription
• Gene expression

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