Neuropeptide Y receptor Y2

Neuropeptide Y receptor Y2 is a protein that in humans is encoded by the NPY2R gene. It is one of the several known receptors for neuropeptide Y, a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including corticotropin-releasing hormone secretion, neuroendocrine function, cardiovascular function, and food intake.

Function

The Neuropeptide Y receptor Y2 is a G protein-coupled receptor that inhibits adenylate cyclase activity. It is involved in a wide array of physiological and pathophysiological processes. It is thought to have a neuroprotective role and is implicated in the control of food intake.

Clinical significance

Alterations in the function of the Neuropeptide Y receptor Y2 have been associated with various diseases, including obesity, anxiety disorders, and depression. It is also being investigated as a potential therapeutic target for the treatment of obesity and anxiety disorders.

See also

• Neuropeptide Y receptor
• Neuropeptide Y
• G protein-coupled receptor

External links

• Neuropeptide Y Receptors: Y2 at the IUPHAR Database

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