ONC1-13B
ONC1-13B is an investigational anticancer drug that is currently under development for the treatment of various types of cancer. It is a small molecule inhibitor that targets specific pathways involved in cancer cell proliferation and survival.
Mechanism of Action[edit | edit source]
ONC1-13B functions by inhibiting the activity of certain tyrosine kinases, which are enzymes that play a critical role in the signaling pathways that regulate cell division and survival. By blocking these kinases, ONC1-13B disrupts the signaling processes that allow cancer cells to grow and divide uncontrollably.
Pharmacokinetics[edit | edit source]
The pharmacokinetic profile of ONC1-13B is characterized by its oral bioavailability, allowing it to be administered in pill form. It is metabolized primarily in the liver and has a half-life that supports once-daily dosing. The drug is excreted mainly through the renal pathway.
Clinical Trials[edit | edit source]
ONC1-13B is currently being evaluated in several clinical trials to assess its efficacy and safety in patients with different types of cancer, including lung cancer, breast cancer, and colorectal cancer. Early-phase trials have shown promising results, with significant tumor reduction observed in some patients.
Side Effects[edit | edit source]
Common side effects of ONC1-13B include nausea, fatigue, and mild myelosuppression. More serious adverse effects, such as hepatotoxicity and cardiotoxicity, have been observed in a small number of patients, necessitating careful monitoring during treatment.
Research and Development[edit | edit source]
The development of ONC1-13B is part of a broader effort to create targeted therapies that offer more effective and less toxic treatment options for cancer patients. Ongoing research is focused on optimizing the drug's efficacy and minimizing its side effects.
Also see[edit | edit source]
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